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The FDA does not usually approve a new brand name just because a drug has a new indication; however, because of the stigma that patients with PAH might associate with taking Viagra, Revatio was approved as a new brand name for sildenafil. Revatio has the approved indication for the treatment of PAH to improve exercise ability; Pfizer viagra official site does not.

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Pfizer viagra official site After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the faeces approximately 80% of administered oral dose and to a lesser extent in the urine approximately 13% of administered oral dose Healthy elderly volunteers 65 years or over had a reduced clearance of sildenafil, resulting in approximately 90% higher plasma concentrations of sildenafil and the active N-desmethyl metabolite compared to those seen in healthy younger volunteers 18-45 years Due to age-differences in plasma protein binding, the corresponding increase in free sildenafil plasma concentration was approximately 40 In volunteers with mild to moderate hepatic pfizer viagra official site Child-Pugh A and B sildenafil clearance was reduced, resulting in increases in AUC 84% and Cmax 47% compared to age-matched volunteers with no hepatic impairment.

The total body clearance of pfizer viagra official site is 41 L/h with a resultant terminal phase half life of 3-5 h. This metabolite has a phosphodiesterase selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% that of the parent drug. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 pfizer viagra official site.

The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil.

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The generic name of the drug is sildenafil (pronounced sill-den-a-fill) Like many great scientific discoveries, the benefits of Viagra in treating erectile dysfunction were discovered by accident. It is also used in the treatment of high blood pressure specific to the heart and the arteries that feed the lungs. ...

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