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Let your doctor know if you have diabetes, have a neurological disease, or have had pelvic surgery or radiation treatments. Current therapy is high dose Advair diskus 500/50 one puff twice daily and Singulair. She was on Xolair therapy for a year and a half with no clinical benefit. This medication comes in a long-acting capsule form and is usually taken once a day.

J Urol. 2006 Jan. -9. ubMed: 4769832Maruyama S, Oki T, Otsuka A, Shinbo H, Ozono S, Kageyama S, Mikami Y, Araki I, Takeda M, Masuyama K, Yamada S: Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder.

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DETROL LA is also contraindicated in patients with known hypersensitivity to the drug or its ingredients, or to fesoterodine fumarate extended-release tablets which, like DETROL LA, are metabolized is detrol la generic 5-hydroxymethyl tolterodine. mg capsules taken orally once daily is detrol la generic water and swallowed whole in the presence of: DETROL LA is not recommended for use in patients with severe hepatic impairment Child-Pugh Class C 2.

DETROL LA is contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma.

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Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

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"We know that OAB is an important medical condition that can dramatically impact quality of life for some sufferers. An estimated 33 million Americans over the age of 18 suffer from OAB, a medical condition which studies have found disrupts generic detrol la activities and sleep, generic detrol la can negatively impact patients' mental health.

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Doing so can destroy the long action of the drug and may increase side effects. To help you remember, use it at the same time each day. Take this medication by mouth with or without food as directed by your doctor, usually once a day. Swallow the medication whole with a full glass of liquid. Do not crush or generic for detrol la the medication. Use this medication regularly to get the most benefit from it.

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In a study evaluating the effect of tolterodine tartrate on cardiac electrophysiology in healthy individuals, a dosage of 4 mg twice daily twice the maximum recommended dosage as conventional tablets is detrol la generic to have a greater effect in prolonging the QTc interval 5.

angioedema have been reported in patients receiving tolterodine during postmarketing surveillance. However, a causal relationship of the drug to some of these effects has not been established.

Urinary tract infection, interstitial cystitis, urinary tract obstruction, diverticulum, bladder tumor, bladder stone have given birth or have had pelvic, vaginal or bladder surgery less than 6 months before study enrollment with a second post-void residual urine volume 150 mL at the time of screening determined by abdominal ultrasound with significant medical problems or other organ abnormality that places them at risk from participating in the study or at a significant risk of developing complete urinary retention with significant impairment of the liver or kidneys as determined by laboratory generic for detrol la or hematuria red blood cells in microscopic urinalysis To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

For general information, Learn About Clinical Studies. Participants who are able to differentiate urinary incontinence episodes associated with urgency from urinary incontinence episodes not associated with urgency during the 7 day baseline period have 21 to 60 urge urinary incontinence Urge-UI episodes, a greater number of Urge-UI episodes than urinary incontinence not associated with urge, and an average of 10 or more voids per 24 hours are in good general health as determined by medical history, physical examination general, genital, pelvic, and rectal laboratory tests and urinalysis and if of child-bearing potential, practicing an generic for detrol la method of birth control, and must have a negative pregnancy test at Visit 2 and Generic for detrol la 3 Participants with known, treatable genitourinary conditions identified on history or on examination that may cause incontinence e.

  • 5 mcM) Since metabolism of tolterodine is mediated by CYP2D6 in individuals with the extensive-oxidizer phenotype Fluoxetine, a potent inhibitor of CYP2D6, substantially inhibits the oxidation pathway responsible is detrol la generic tolterodine's metabolism is detrol la generic extensive metabolizers; therefore, the pharmacokinetic profile of patients receiving fluoxetine and tolterodine concomitantly resembles that of poor metabolizers. However, tolterodine has been shown to inhibit CYP2D6 in vitro at high concentrations (KI 1.
  • Be sure to include a copy of the front of your DETROL LA Savings Card, your name, and mailing address. om for more information about DETROL LA. For help with the DETROL LA Savings Offer Program, call 1-855-541-5932, or write: Pfizer Inc. 235 E 42nd Street, New York, NY 10017 If your pharmacy does not participate, you may be able to submit a request for a rebate in connection with this Savings Offer. Pay for your DETROL LA prescription and mail copy of original pharmacy receipt (cash generic for detrol la receipt NOT valid) with product name, date, and amount circled to: DETROL LA Generic for detrol la Offer, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560.
  • Follow the directions on your prescription label. Take Detrol exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. detrol la generic brand
  • These observations should be considered when use of tolterodine is contemplated in patients with a history of QT interval prolongation or in patients receiving generic for detrol la IA (e. (See Cautions: Cardiovascular Effects.
  • Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. For current full prescribing information, please visit Product TypeHUMAN PRESCRIPTION DRUGItem Code generic detrol la DC: 5289-13 (NDC: 009-5191) 1NDC: 5289-132-2121in 1 Generic detrol la, PLASTIC; Type 0: Not a Combination Product. 2NDC: 5289-132-3030in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product. generic detrol la

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Ng/mL were achieved within 4 hours, while serum 5-hydroxymethyl metabolite concentrations averaged 1. In addition, in healthy men with the extensive-oxidizer phenotype receiving multiple 4-mg doses of tolterodine tartrate as extended-release capsules, peak serum 5-hydroxymethyl metabolite concentrations of 2.

In healthy men with extensive-oxidizer phenotypes receiving single doses of tolterodine tartrate, using data normalized for a single generic of detrol la dose as extended-release capsules peak serum 5-hydroxymethyl metabolite concentrations of 1.

ng/mL. In one phase I study, following oral administration of tolterodine tartrate dosages of 2 mg twice daily as conventional tablets generic of detrol la healthy geriatric adults 64-80 years of age generic of detrol la concentrations of tolterodine and its 5-hydroxymethyl metabolite were similar to those observed in healthy individuals younger than 40 years of age. ng/mL were achieved within 4 hours, while serum concentrations of the metabolite averaged 1 ng/mL.

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A 27-month-old child who ingested 5 to 7 tolterodine immediate release 2 is detrol la generic tablets was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. and CLINICAL PHARMACOLOGY 12. ECG monitoring is recommended in the event of overdosage. mg/kg, which is about 68 times higher than the recommended human dose.

In clinical trials of normal volunteers and patients, QT interval prolongation was observed with tolterodine immediate release at doses up to 8 mg 4 mg bid and higher doses were not evaluatedsee WARNINGS AND PRECAUTIONS 5.

In dogs, changes in the QT interval slight is detrol la generic of 10% to 20% were observed at a suprapharmacologic dose of 4.

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EtailsCytochrome P450 2D6CYP2D6*62Not Available4044CTEffect InferredPoor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Generic for detrol la. etailsCytochrome P450 2D6CYP2D6*68ANot Available-1426CG show all Effect InferredPoor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade generic for detrol la Pointes.

etailsCytochrome P450 2D6CYP2D6*57Not Available100CT show all Effect InferredPoor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.

Symptoms of a serious allergic reaction may include swelling of the face, lips, throat, or tongue. If you took more than your prescribed dose of Detrol LA, call your doctor or poison control center, or go to the hospital emergency room.

If you experience these symptoms, you should stop taking Detrol LA and get emergency medical help right away. Detrol LA may cause allergic reactions that may be serious. detrol la generic brand

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Dry mouth was similar between patients receiving conventional tolterodine detrol la generic brand and extended-release oxybutynin. For the management of urge urinary incontinence, urgency, and frequency in patients with overactive bladder, the usual initial adult dosage of tolterodine tartrate is 2 mg twice daily as conventional tablets or 4 mg once daily as extended-release capsules.

Dosage may be reduced to 1 mg twice daily as conventional tablets or 2 detrol la generic brand once daily as extended-release capsules according to individual response and tolerance. episodes per week, respectively The incidence of adverse effects e.

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6 or 5. 4 msec increase from baseline as measured by machine or manually, respectively than a dosage of 2 mg twice daily 1.

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Episodes per week, respectively and a decreased number of total incontinence episodes from a mean of 28. or from a mean of 27 to 9. to 7. to 7.

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Capsules have pharmaceutical grade printing ink that contains shellac glaze, titanium dioxide, propylene glycol, and simethicone. om on the Internet, or call 1-888-4-DETROL 1-888-433-8765 Inactive ingredients: sucrose, starch, hypromellose, ethylcellulose, medium chain triglycerides, detrol la generic brand acid, gelatin, and FD C Blue #2.

This product's label may have been updated. 2 mg capsule also contains yellow iron oxide.

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There may be other options. Ask your doctor if DETROL LA is right for you. DETROL LA has both benefits and risks.

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Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers. 2 year old male with overactive bladder symptoms for 15 years. This material is provided for educational purposes only and is not intended for medical advice, diagnosis generic detrol la treatment.

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There are 2 major patterns of tolterodine metabolism. 8-mg dose of tolterodine tartrate in humans, the volume of generic of detrol la of tolterodine is about 113 L. It is not known whether tolterodine crosses the placenta or is distributed into breast milk in humans; owever, the drug is distributed into milk in mice.


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Product evaluations detrol la – 9 amount:

Comment #1 - 4 stars detrol la 4 mg: author , in

Anaphylaxis and angioedema can be life-threatening and require immediate is detrol la generic attention. Tolterodine may cause serious types of allergic reactions, including anaphylaxis and angioedema.

It is very important that your doctor check your progress at regular visits. Stop using this medicine and call your doctor right away if you have is detrol la generic rash; itching; hoarseness; lightheadedness, dizziness, or fainting; trouble breathing; trouble swallowing; or any swelling of your hands, face, mouth, or throat after using this medicine.

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This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Comment #2 — 2 stars detrol la 4 mg: author , in

You can ask your doctor or pharmacist for information about DETROL LA that is written for health professionals. It may harm them. This leaflet detrol la generic brand the most important information about DETROL LA. If you would like more information, talk with your doctor. detrol la generic brand

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I hope this sheds some light on your question. Good luck. What is the recommended dosage form of propantheline for example or any other anticholinirgic drug in order to decrease the side effects as much as generic of detrol la can?

If one type of anti cholinergic agents fails then there are few others on the market and you can try switching from one generic of detrol la another to find out which one is the best for you.

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Tolterodine generic detrol la also negative in vivo in the bone marrow during gestation with 20 mg/kg/day corresponding to AUC value of about 500 were seen. No increase in tumors was found battery of in vitro tests, including bacterial mutation assays Ames test generic detrol la 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in L5178Y mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes. generic detrol la

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In vitro data show that tolterodine immediate release is a competitive inhibitor of CYP2D6 at high concentrations K No mutagenic or genotoxic effects of tolterodine were detected in a battery of in vitro tests, including bacterial mutation assays Ames test in 4 strains of Escherichia coli, a gene mutation assay generic for detrol la L5178Y mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes or terbinafine hydrochloride cream reviews.

In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole. generic for detrol la

Comment #6; 5 stars detrol la 4 mg: author , in

Is detrol la generic Is detrol la generic all medications away from children and pets. Properly discard this product when it is expired or no longer needed. Do not store in the bathroom. o not flush medications down the toilet or pour them into a drain unless instructed to do so.

Comment #7; 4 stars detrol la 4 mg: author , in

There are no available data with DETROL LA detrol la generic brand in pregnant women to inform detrol la generic brand risks, -fold, respectively, in CYP2D6 poor metabolizers. For patients receiving ketoconazole or other potent CYP3A4 inhibitors such as itraconazole, clarithromycin, or ritonavir, the recommended detrol la generic brand of DETROL LA is 2 mg once daily No clinically relevant interactions have been observed when tolterodine was co-administered with warfarin, with a combined oral contraceptive drug containing ethinyl estradiol and levonorgestrel, or with diuretics In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole The concomitant use of DETROL LA with other anticholinergic antimuscarinic agents may increase the frequency and/or severity of dry mouth, constipation, blurred vision, somnolence, and other anticholinergic pharmacological effects.

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Generic for detrol la Excretion: Following administration of a 5 mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days.

The remainder of the population is referred to as "extensive metabolizers. Less than. Pharmacokinetic studies revealed that tolterodine is metabolized at a slower rate in poor metabolizers than in extensive metabolizers; this generic for detrol la in significantly higher serum concentrations of tolterodine and in negligible concentrations of 5-HMT.

Comment #9; 4 stars detrol la 4 mg: author , in

To evaluate the efficacy of 5 and10mg solifenacin succinate in patients with urgency who have OAB syndrome urgency, with or without urge incontinence, usually with frequency and nocturia and wish to switch from tolterodine tartrate extended release to solifenacin succinate due to lack of sufficient improvement in urgency episodes An Open-Label Multicenter Study to Assess the Efficacy and Safety of Daily Oral Administration of 5 and 10mg VESIcare Solifenacin Succinate in Patients Who Wish to Switch From Detrol LA Tolterodine Tartrate Extended Release for the Treatment of Overactive Bladder Symptoms Versus: VESIcare Efficacy and Research Study US To assess the improvement in urge incontinence, frequency, octuria, and urgency Time Frame: Weeks 1, 4, 8 and 12 Number of patients satisfied with treatment Time Frame: Weeks 1, 4, 8 and 12 Evaluation of the safety and tolerability Generic of detrol la Frame: Baseline to end of study Choosing to participate in a study is an important personal decision.

Listing a study does not mean it has been evaluated by the U. Federal Government. generic of detrol la

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