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To help you remember, use it at the same time each day. The dosage is based on your medical condition (especially kidney and liver disease) response to treatment, and other medications you may be taking. Detrol la (tolterodine) packing 4 mg 10 amount of packaging.

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2002 Nov. 6 5 Suppl 1 72-6; discussion 77. Medline. Urology.

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However, because of extensive first-pass metabolism in the liver, the absolute oral bioavailability of tolterodine is variable 10-74% and may depend generic for detrol la a patient's genetically determined ability to metabolize the drug. In most patients those with the extensive-oxidizer phenotype tolterodine undergoes extensive first-pass metabolism in the liver, producing the major active 5-hydroxymethyl metabolite.

Studies in adults with renal impairment or liver cirrhosis indicate that the pharmacokinetics of generic for detrol la are affected substantially by renal or hepatic impairment. See In healthy individuals, at least 77% of a radiolabeled dose of tolterodine tartrate is rapidly absorbed from the GI tract.

Peak serum concentrations of the drug usually occur within 1-2 or 2-6 hours after administration of a dose as generic for detrol la tablets or extended-release capsules, respectively.

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Generic for detrol If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation should be considered. Patients should be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose.

Advise patients not to drive or operate heavy machinery until the drug's effects have been determined.

Tolterodine acid were approximately 10- to 30-fold higher in these patients than in healthy individuals. Serum concentrations of tolterodine tartrate and its metabolites appear to be higher in patients with renal impairment than in healthy individuals. Following administration of conventional tablets of tolterodine tartrate, serum concentrations of tolterodine and its 5-hydroxymethyl metabolite were approximately 2- to 3-fold higher in is detrol la generic with renal impairment creatinine clearance of 10-30 mL/minute compared with those observed in healthy individuals.

See Dosage and Administration: Dosage in Renal and Hepatic Impairment. Serum concentrations of other metabolites e.

Generic of detrol la The effectiveness of DETROL LA has not been established in pediatric patients, No overall differences in safety were observed between the older and younger patients treated with tolterodine.

In multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of 5-HMT were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years In another clinical study, elderly volunteers aged 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid Mean serum concentrations of tolterodine and 5-HMT in these elderly volunteers were approximately 20% and 50% higher, respectively, than concentrations reported in young healthy volunteers.

Based on limited data, tolterodine is excreted into the milk in mice in low amounts see Data The development and health benefits of breastfeeding should be considered along with the mother's clinical need for DETROL LA and any potential adverse effects on the breastfed infant from DETROL LA or from the underlying maternal condition.

There are no available data with DETROL LA use in pregnant women to inform drug-associated risks. In animal reproduction studies, oral administration of tolterodine and its 5-HMT metabolite to pregnant mice during detrol la generic brand did not produce adverse developmental outcomes at doses approximately 9 to 12 times the clinical exposure at a dose of 20 mg/kg/day; however, higher doses produced adverse developmental outcomes see Data There is no information on the presence of tolterodine generic of detrol la its 5-HMT metabolite in human milk, the effects on the breastfed infant, or generic of detrol la effects on milk production.

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Generic detrol la etailsCytochrome P450 2D6CYP2D6*92Not Available1995delCEffect InferredPoor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association generic detrol la drug with Torsade de Pointes. ffect InferredPoor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes. etailsCytochrome P450 2D6CYP2D6*69Not Available2988GT show all Effect InferredPoor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.

2. Novara G, Galfano A, Secco S, et al. 06. Reviews in Urology.

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Beats/minute following administration of tolterodine 2 mg twice daily or 4 mg twice daily, respectively. eart rate increased by a mean of 2 or 6. 6 or 5. 1 msec increase from baseline as measured by machine or manually, respectively Prolongation of the QTc interval was found to correlate with plasma tolterodine concentration and was more pronounced in individuals with the poor-oxidizer phenotype than generic for detrol la 4mg those with the extensive-oxidizer phenotype.

This combination hormone medication is used to prevent pregnancy. It contains 2 hormones: a progestin and an estrogen. It works mainly by preventing t.

In healthy men with extensive-oxidizer phenotypes receiving single doses of tolterodine tartrate, using data normalized for a single 4-mg dose as extended-release capsules peak serum 5-hydroxymethyl metabolite concentrations of 1 or himcolin gel hindi me jankari.

or 19 ng/mL, respectively, were achieved within 4 hours, while detrol la generic brand serum concentrations were 1. ng/mL were achieved within 4 hours, while serum concentrations of the metabolite averaged 1 ng/mL. or 13 ng/mL, respectively.

  • Is detrol la generic is detrol la generic different shape or color) as trademarks laws prevent a generic from looking exactly like the brand-name drug. The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg.
  • Discuss the risks and benefits with your doctor. During pregnancy, this medication should be used only when clearly needed.
  • It is not known whether tolterodine is distributed into human milk. When administered for 2 weeks generic detrol la to mating and during gestation in female mice, tolterodine tartrate dosages of generic detrol la mg/kg daily (about 15 times the human systemic exposure based on AUC comparisons) were not associated with impairment of fertility or reproductive performance. In addition, in male mice receiving tolterodine tartrate dosages of 30 mg/kg daily, no adverse effects on fertility were observed.
  • Review anticholinergic drug side effects, drug interactions, storage, dosing, and pregnancy and safety information prior to taking this medication. Anticholinergic or antispasmodic drugs include prescription medications used to treat a variety of medical conditions. generic of detrol la
  • This study evaluated the efficacy and safety of solifenacin and tolterodine in Taiwanese patients with OAB symptoms. Both solifenacin and tolterodine are effective in treating key OAB symptoms, including urinary frequency, urgency and incontinence is detrol la generic the Taiwanese population. Various antimuscarinic agents have been developed for the treatment of overactive bladder (OAB) More data comparing these agents are still required. is detrol la generic
  • Medscape Medical News. Available at ww. Doheny K. FDA OKs First OTC Remedy for Overactive Generic of detrol la
  • This third-party website is neither owned nor controlled by Pfizer, and Pfizer does not endorse and is not responsible for the content or services of this sitePfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, is detrol la generic medicines for free or at a savings. Patients and physicians can contact RxPathways at. Links to sites outside of Pfizer Medical Information are provided as a resource to is detrol la generic viewer.

Amiodarone, sotalol antiarrhythmic medications. Other Anticholinergics antimuscarinics Concomitant use with other anticholinergic agents may increase the frequency generic for detrol severity of dry mouth, constipation, blurred vision, and other anticholinergic pharmacological effects. quinidine, procainamide or Class III e. Hepatic Impairment: Not recommended for use in severe hepatic impairment Child Pugh Class C Dose adjustment in mild to moderate hepatic impairment Child Pugh Class A, B The recommended dose of DETROL LA Capsules is 4 mg once daily with water and swallowed whole.

To generic for detrol SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc at 1-800-438-1985 or FDA at 1-800-FDA-1088 or Potent CYP3A4 Inhibitors: Coadministration may increase systemic exposure to DETROL LA. Reduce DETROL LA dose to 2 mg once daily. generic for detrol

The Pfizer Patient Detrol la generic brand Foundation is a separate legal entity from Pfizer Inc. with distinct legal restrictions. This enrollment form is for patients who would like to apply to detrol la generic brand any of the Group B medicines listed below for free through the Pfizer Patient Assistance Program. Do I qualify detrol la generic brand receive free medicine through the Pfizer Patient Assistance Program?

Note: Income limits are subject to change on an annual basis; current limits reflect 2019 Federal Poverty Level Guidelines. The Pfizer Patient Assistance Program is a joint program of Pfizer Inc. and the Pfizer Patient Assistance FoundationTM. The Pfizer Patient Assistance Program is a joint program of Pfizer Inc.

and the Pfizer Patient Assistance FoundationTM.

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Generic detrol la active 5-hydroxymethyl metabolite, which is the predominant species in extensive metabolizers, is more than 350 times less lipophilic than oxybutynin.

2 Despite those arguments, there are at least 3 reasons that, alone or in combination, may explain why our patient suffered memory problems secondary to tolterodine therapy. Another argument generic detrol la the relatively generic detrol la penetrance across the blood-brain barrier of tolterodine and its metabolites as measured in mice21 and as suggested by the lipophilicity of the active compounds. Tolterodine is more than 30 times less lipophilic than oxybutynin.

0 Such measurements, however, may not fully predict if an agent can induce amnesia.

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As requested by the Government of Japan, deliveries of the vaccine candidate are planned for the first half of 2021.

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Tell your doctor or prescriber about all prescription, over-the-counte non-prescription and herbal medications that you are taking. Medications other than those listed above may interact with thismedication.

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Seems to be caused by nerve damage in lumbar vertebra. Was going to bathroom every twenty minutes. Detrol LA tolterodine 62 year old male with overactive bladder symptoms for 15 years.

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In addition, in healthy men with the extensive-oxidizer phenotype receiving multiple 4-mg doses of tolterodine tartrate as extended-release capsules, peak serum 5-hydroxymethyl metabolite concentrations of 2. generic detrol la were achieved within 4 hours, while serum 5-hydroxymethyl metabolite concentrations averaged 1. ng/mL were achieved within 4 hours, while serum concentrations of the metabolite averaged 1 ng/mL.

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DETROL LA Capsules contain tolterodine tartrate. mg/kg, which is about 68 times higher than the recommended human dose or In clinical trials of normal volunteers and patients, QT interval prolongation was observed with tolterodine immediate release at doses up to 8 mg 4 mg bid and higher doses were not evaluated A 27-month-old child who ingested 5 to 7 tolterodine immediate release 2 mg is detrol la generic was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth.

The child fully recovered.


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The most common adverse events reported by patients receiving DETROL LA were dry mouth, headache, constipation, and abdominal pain. Dry mouth was the most frequently reported adverse event for patients treated with DETROL LA, occurring in 23. These included a total of 1012 patients (505 randomized to DETROL LA 4 mg once daily and 507 randomized to placebo) enrolled in a randomized, placebo-controlled, double-blind, 12-week clinical of patients receiving placebo. ...