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Bystolic can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists particularly of the phenylalkylamineverapamiland benzothiazepinediltiazemclasses or antiarrhythmic agents, such as disopyramide. There are risks to the mother and fetus associated with poorly controlled hypertension in pregnancy. The use bystolic coupon cvs beta blockers during the third trimester of pregnancy may increase the risk of hypotension, bradycardia, hypoglycemia, and respiratory depression bystolic coupon cvs the neonate see Clinical Considerations.

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The doctor may recommend 24-hour blood pressure monitoring to exclude "white coat" hypertension. These scenarios are not synonymous. Sometimes, "white coat" hypertension is mistaken for resistant hypertension. With "white coat" hypertension, the patient may have a rise in blood pressure at the doctor's office bystolic manufacturer discount not at home.

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